Model-prediction exposures

Model-prediction exposures

expo

Format

A data frame with 2436 rows and 17 variables, providing the exposures for 812 individuals at 3 different dose levels

ID

Subject ID

DOSE

Dose (mg)

AGE

Age (y)

WTKG

Body weight (kg)

BMI

Body mass index (kg/m2)

SEXF

Sex

RFCAT

Renal function category

CPCAT

Child-Pugh category

HFM

Meal status

CL

Elimination clearance (L/h)

V

Volume of distribution (L)

KA

First-order absorption rate (1/h)

F1

Relative bioavailability (-)

AUCSS

Steady-state area under the curve (nmol*h/L)

TMAXSS

Steady-state time to maximum concentration (h)

CMAXSS

Steady-state maximum concentration (nmol/L)

CMINSS

Steady-state trough concentration (nmol/L)